Several methods have been developed to compensate for matrix interferences, and most atomic absorption spectrophotometers include one or more of these methods. One of the most common methods for background correction is to use a continuum source, such as a D 2 lamp. The types of spectral interferences most commonly encountered for. This article provides a comprehensive guide for researchers and drug development professionals on overcoming chemical interference in spectrophotometric analysis. This document provides in-depth, field-proven insights and actionable protocols. ICP-MS serves as a powerful elemental detection method for accurate and precise analysis, especially for quantification purposes.